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Researcher

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Dayna Daubaras, Ph.D.

Science and Engineering Research Scientist

Research Areas:
Critical Materials; ​Advanced Preprocessing

Biography:
Dr. Dayna Daubaras is a science and engineering research scientist in Idaho National Laboratory’s Chemical and Biological Processing Department. She holds a doctorate in microbiology and immunology from the University of Illinois, Chicago and a bachelor’s in microbiology from University of Illinois, Urbana-Champaign. Her work involves Researching and developing extremophilic enzymes for environmental and industrial applications. She has genetically engineered Archaea using synthetic biology for chemical production, performed organic chemical synthesis and NMR analysis for various projects, characterized unique acid-thermal stable enzymes for pre-treatment of lignocellulosic biomass, and performed High Performance Liquid Chromatography analysis of carbohydrates, organic acids, and aromatic compounds. Before coming to INL in 2009, she worked at Schering-Plough Research Institute as an associate principal scientist, leading a team of chemists, structural chemists, and outside consultants on lead discovery projects and presenting quarterly to senior management.

Education:

​Ph.D., Microbiology/Immunology - University of Illinois

B.S., Microbiology - University of Illinois

Publications:
​Articles

 
Rollins H.W., M.K. Harrup, E.J. Dufek, D.K. Jamison, S.V. Sazhin, K.L. Gering,  D.L. Daubaras.  Fluorinated Phosphazene Co-solvents for Improved Thermal and Safety Performance in Lithium-ion Battery Electrolytes.  J. of Power Sources (2014) 263(1) 66-74.

 
Mansoor, U.F., D. Vitharana, P.A. Reddy, D.L. Daubaras, P. McNicholas, P. Orth, T. Black, M.A. Siddiqui.  Design and Synthesis of Potent Gram-negative Specific LpxC Inhibitors. Bioorg Med Chem Lett. (2011) 21(4):1155-61.

 
Langsdorf, E.F., A. Malikzay, W.A. Lamarr, D. Daubaras, C. Kravec, R. Zhang, R. Hart, F. Monsma, T. Black, C.C. Ozbal, L. Miesel, C.A. Lunn.  Screening for Antibacterial Inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase (LpxC) Using a High-throughput Mass Spectrometry Assay. J Biomol Screen. (2010) 1:52-61.

 
Daubaras, D.L., E.M. Wilson, T. Black, C. Strickland, B.M. Beyer and P. Orth. Crystallization and Preliminary X-ray Analysis of the Acyl Carrier Protein Synthase (AcpS) from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr (2004) 60: 773-774.

 
Zhang, N., D.L. Daubaras, and W.-C. Suen. Heterologous Protein Expression in Yeasts and Filamentous Fungi.  In An, et al. (ed.), Handbook of Industrial Mycology. Marcel Dekker, Inc., New York, NY (2004) 667-687.

 
Zaborina, O., D.L. Daubaras, A. Zago, L. Xun, K. Saido, T. Klem, D. Nikolic, and A.M. Chakrabarty. Novel Pathway for Conversion of Chlorohydroxyquinol to Maleylacetate by Burkholderia cepacia AC1100. J. Bacteriol. (1998) 180:4667-4675.

 
Chugani, S., D.L. Daubaras, C.E. Danganan, A. Hubner, S. McFall, W. Hendrickson, and A.M. Chakrabarty. Molecular and Evolutionary Mechanisms in the Microbial Degradation of Synthetic Chlorinated Compounds. Chim. Oggi (1997) 15:17-23.

 
Danganan, C.E., M.R. Parsek, S.M. McFall, D.L. Daubaras, and A.M. Chakrabarty. Biodegradation of Toxic Aromatic Compounds: an Evolutionary Perspective. In Biomacromolecules: from 3-D Structure to Applications. (1997) p.265-280. The 34th Hanford Symposium on Health and the Environment, 1995.

 
Daubaras, D.L., C.E. Danganan, R.W. Ye, A. Hübner, W. Hendrickson, and A.M. Chakrabarty. Biodegradation of 2,4,5-Trichlorophenoxyacetic Acid by Burkholderia cepacia AC1100: Evolutionary Insight. Gene (1996) 179:1-8.

 
Daubaras, D.L., K. Saido, and A.M. Chakrabarty. Purification of Hydroxyquinol 1, 2-Dioxygenase and Maleylacetate Reductase: the Lower Pathway of 2,4,5-Trichlorophenoxyacetic Acid Metabolism by Burkholderia cepacia AC1100. Appl. Environ. Microbiol. (1996) 62:4276-4279.

 
Kasberg, T., D.L. Daubaras, A.M. Chakrabarty, D. Kinzelt, and W. Reineke.  Evidence that Operons tcb, tfd, and clc Encode Maleylacetate Reductase, the Fourth Enzyme of the Modified ortho Pathway. J. Bacteriol. (1995) 177:3885-3889.

 
Daubaras, D.L., C.D. Hershberger, K. Kitano, and A.M. Chakrabarty. Sequence Analysis of a Gene Cluster Involved in the Metabolism of 2,4,5-Trichlorophenoxyacetic Acid by Burkholderia cepacia AC1100. Appl. Environ. Microbiol. (1995) 61:1279-1289.

 
Danganan, C.E., R.W. Ye, D.L. Daubaras, L. Xun, and A.M. Chakrabarty. Nucleotide Sequence and Functional Analysis of the Genes Encoding 2,4,5-Trichlorophenoxyacetic Acid Oxygenase in Pseudomonas cepacia AC1100. Appl. Environ. Microbiol. (1994) 60:4100-4106.

 
Daubaras, D.L., and A.M. Chakrabarty. The Environment, Microbes and Bioremediation: Microbial Activities Modulated by the Environment. Biodegradation (1992) 3:125-135.

 

 

 
Meeting Abstracts

 
Reed, D.W., D.L. Daubaras, J.M. Barnes, V.S. Thompson, W.A. Apel, and D.N. Thompson. Development of a novel thermoacidophilic endo-1,4-β-xylanase. 63rd Society for Industrial Microbiology and Biotechnology Annual Meeting. August 11-15, 2013, San Diego, California.

 
Malikzay, A., E.F. Langsdorf, L. Miesel, D.L. Daubaras, C. Kravec, R. Zhang, W.A. LaMarr, C. Ozbal, M. Bayne, R. Hart, F. Monsma, T. Black, and C.A. Lunn.  Screening LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using BioTrove RapidFire HTS Mass Spectrometry. (2006) Society for Biomolecular Sciences, 12th Annual Conference and Exhibition.

 
Suen, Wen-Chen, D.L. Daubaras, N. Zhang, and A. Zaks.  Expression of Lipase B from Candida antarctica in Saccharomyces cerevisiae, Aspergillus niger, Pichia pastoris, and Pichia methanolica. (2002) Biocat 2002, 1st International Congress on Biocatalysis. Hamburg, Germany  

 
Saido, K., D.L. Daubaras, O.E. Zaborina, and A.M. Chakrabarty. Biodegradation of 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and Analysis of the Degradation Products. (1998) The 24th Symposium on Environmental Pollutants and Toxicology. Osaka, Japan

 
Zaborina, O.E., D.L. Daubaras, T.J. Klem., and A.M. Chakrabarty. Novel Enzymes Involved in the Dechlorination of 5-Chlorohydroxyquinol: an Intermediate in 2,4,5-T Degradation. (1998) Annu. Meet. Am. Soc. Microbiol.  Atlanta, GA

 
Zago, A., D.L. Daubaras, and A.M. Chakrabarty. Regulation in Burkholderia cepacia AC1100 of the 2,4,5-Trichlorophenoxyacetic Acid Lower Pathway Gene Cluster. (1997) Annu. Meet. Am. Soc. Microbiol.  Miami, FL

 
Saido, K., D.L. Daubaras, and A.M. Chakrabarty. Biodegradation of 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and Analysis of the Degradation Products. (1996) The 22nd Symposium on Toxicology and Environmental Health.  Niigata, Japan

 
Daubaras, D.L., K. Saido, and A.M. Chakrabarty. The Lower Pathway of 2,4,5-Trichlorophenoxyacetic Acid Metabolism Requires A Novel Dechlorinase. (1996) Biodegradation Symposium.  Mallorca, Spain

 
Daubaras, D.L. and A.M. Chakrabarty. Biodegradation of 2,4,5-Trichlorophenoxyacetic Acid: a New Modified ortho Pathway. (1996) Annual UIC Student Research Forum.  Chicago, IL

 
Daubaras, D.L. and C.D. Hershberger. Cloning and Sequencing of a Gene Involved in 2,4,5-Trichlorophenoxyacetic Acid Degradation by Pseudomonas cepacia AC1100.  (1994) Annu. Meet. Am. Soc. Microbiol.  Las Vegas, NV

 
Danganan, C.E., R.W. Ye, and D.L. Daubaras. Cloning and Sequence Analysis of 2,4,5-T Oxygenase Genes in Pseudomonas cepacia AC1100. (1994) Annu. Meet. Am. Soc. Microbiol.  Las Vegas, NV

 
Daubaras, D.L., K. Kitano, and A.M. Chakrabarty. Characterization of Genes Involved in 2,4,5-Trichlorophenoxyacetic Acid Degradation by Pseudomonas cepacia AC1100. (1992) Annu. Meet. Am. Soc. Microbiol.  New Orleans, LA
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Created at 12/16/2015 1:21 PM by Phyllis L. King
Last modified at 4/17/2019 2:12 PM by hailey.goddard@inl.gov